This chew is made with a naturally abrasive beef rawhide and treated with Biotrate™ Technology to promote good oral hygiene through a chewing action which helps to freshen breath and fight tartar. One chew per day as part of an overall oral hygiene program Biotrate technology combines with the mechanical action of the chew for enhanced performance Beef rawhide, dextrose, poultry digest, maltodextrin, hydrolyzed vegetable protein, potassium sorbate, dried yeast, water, trisodium citrate, citric acid, disodium EDTA, glycerol, xanthan gum, potassium benzoate, zinc chloride The large size are ideal for Dogs between 12kg and 30kg, and over 9 months of age.